Abstract: Based on the basic data of on-site water transmission pipeline, OLGA was used to simulate the pipeline flow parameters, and the corrosion sensitive area and its working condition parameters were determined. According to the working condition parameters, the high-temperature and high-pressure reactor experiment was formulated, and the corrosion degree in the pipeline was determined. Combined with multiple linear regression method, the corrosion prediction model was established. The results showed that the experimental corrosion rate ranged from 0. 064 8 to 0. 105 6 mm/a under the condition of the simulation of corrosion sensistive area of the pipeline, and the internal corrosion was moderate. The corrosion prediction model was established, and the maximum error was 3. 9%, which indicated that the model had high accuracy.