Abstract: Based on multiphase flow numerical simulation and the De Waard95 CO₂ corrosion model, the variation of CO₂ corrosion rate along pipelines under temperature ranges of 70-90 ℃, pressure ranges of 15-18 MPa, transmission capacities of 35-50 kg/s, and inclination angles of 15°-60 ° was examined in order to shed light on the distribution and effects of CO₂ corrosion along pipelines under harsh operating conditions, such as high temperature, high pressure, and large transmission capacity. The findings indicate that the corrosion rate was the highest on the downhill portion of the pipeline and that the inflection point of corrosion rate along the pipeline corresponded with the inflection point of elevation change. The maximum corrosion rate was most sensitive to changes in medium temperature, followed by operating pressure; corrosion control should concentrate on medium temperature, operating pressure, and downhill sections. Temperature, pressure, flow rate, and pipeline inclination had no effect on the distribution of corrosion rate.