Abstract: The CRUD deposited on the fuel cladding surface in a pressurized water reactor (PWR) core will reduce heat transfer efficiency, alter local water chemistry, cause axial power shifts and even accelerate the under-deposit corrosion of fuel cladding materials, and thus threaten the safety and stable operation of the reactor units in nuclear power plants (NPPs). This paper summarizes the key factors influencing the CRUD deposition on the surface of fuel cladding and their action rules, with a focus on analyzing the effect of zinc injection water chemistry on the CRUD deposition behavior on the cladding surface. It also provides a detailed introduction to the currently more mature CRUD deposition prediction models and analyzes the applicability of the prediction models through comparison with experimental data.