Abstract: In view of the frequent corrosion perforation failures of produced water system pipelines in Kuqa Piedmont gas field, based on the statistical analysis of on-site corrosion distribution characteristics, corrosion tests were carried out using a high-temperature and high-pressure dynamic reactor to simulate actual on-site working conditions. The corrosion resistance of four commonly used pipeline materials, namely L245, 316L, 22Cr and P110, was quantitatively studied and evaluated. The results show that L245 material suffered severe corrosion with a uniform corrosion rate of 0.201 0 mm/a, belonging to the severe corrosion grade. 316L and 22Cr materials undergo slight corrosion, with uniform corrosion rates of 0.005 7 mm/a and 0.001 1 mm/a respectively, both being mild corrosion without obvious pitting. P110 material experienced moderate uniform corrosion (uniform corrosion rate 0.065 1 mm/a) and extremely severe pitting, with a pitting rate as high as 0.938 6 mm/a. Based on the test results, it is recommended that 316L or 22Cr materials be used for surface process pipelines and other facilities of drainage wells, non-metallic materials such as glass fiber reinforced plastic and flexible composite pipes be adopted for buried pipelines from drainage wells to subsequent processes, and carbon steel materials be selected for gas phase pipelines after gas-liquid separation to balance economy and applicability.