Preparation and Biological Properties of Tannic Acid/Alcohol-Soluble Chitosan Compound

Alcohol-soluble chitosan was prepared through two-step method, and its structure was characterized by nuclear magnetic resonance spectrometer (NMR). Tannic acid/alcohol-soluble chitosan compound with microporous structure was synthesized by adding different masses of tannic acid and alcohol-soluble chitosan. This compound was characterized by scanning electron microscope (SEM) and thermogravimetric analyzer. The results show that the obtained compound had microporous structure and the pore size was below 100 nm when the mass ratio of alcohol-soluble chitosan to tannic acid was 3∶1. The compound had a bacteriostatic rate of 75% and a hemolysis rate of 0.3%, and had a good antibacterial property and biocompatibility.